| | Name | Platforms | Developer | Publisher | |
|---|
| Senhor Abraço Teaser Jogável | ItchIo | Menos Playstation | | |
| Senile Showdown: Arthfightus | ItchIo | Scythe Dev Team | | |
| Senioritis | ItchIo | ScaryGnomeStudios | | |
| Senjyo | Arcade | | Tecmo | |
| Senkai Ibonroku Juntei Taisen: TV Animation Senkaiden Houshin Engi Yori | GBC | | Banpresto | |
| Senkai Taisen: TV Animation Senkaiden Fuukami Engiyori | PS1 | Opera House | Bandai | |
| Senkai Tsuuroku Seishi | PS1 | Opera House | Bandai | |
| Senkaiden: TV Animation Senkaiden Houshin Engi Yori | Wonderswan | Graphic Research Co., Ltd | Bandai | |
| Senken Kigyouden | SegaSaturn | Softstar Entertainment | Softstar Entertainment | |
| Senko no Ronde 2 旋光の輪舞２ | Steam | | | |
| Senko no Ronde: Duo | XBOX360 | G.rev | G.rev | |
| Senkutsu Katsuryuu Taisen Chaos Seed | SegaSaturn | Neverland CompanyEntertainment Software Publishing | Neverland Company | |
| Senna and the Forest | Steam | | | |
| Sennen Kazoku | GBA | Indies Zero | Nintendo | |
| Senpai Simulator | ItchIo | Brainscraps | | |
| Senpai Teaches Me Japanese | Steam | | | |
| Senpai, Please Look At Me! | ItchIo | Tokkimeki | | |
| Senpai, Please don't notice me! | ItchIo | eggshelly | | |
| Senran | PS1 | Angel | Angel | |
| Senran Kagura 2: Deep Crimson | 3DS | Marvelous AQL | Marvelous AQL | |
| Senran Kagura Burst | 3DS | Marvelous AQL | Marvelous AQL | |
| Senran Kagura: Peach Ball | Switch | Marvelous | Marvelous | |
| Senran Kagura: Reflexions | Switch | Marvelous | NA: Xseed GamesPAL: Marvelous | |
| Senran Kagura: Shōjo-tachi no Shin'ei | 3DS | Marvelous Entertainment | Marvelous Entertainment | |
| Senren＊Banka | Steam | | | |
| Senri no Kifu: Gendai Shougi Mystery | Switch | Kemco | Kemco | |
| Senryaku Shidan: Tora! Tora! Tora! Rikusenhen | PS1 | Nexus Interact | Dazz | |
| Senryaku Shogi | PS1 | Electronic Arts Victor | Electronic Arts Victor | |
| Senryaku Shougi | SegaSaturn | Electronic Arts Victor | Electronic Arts Victor | |
| Sense | ItchIo | Christos Kalanidis | | |
| Sense - 不祥的预感 : A Cyberpunk Ghost Story (OLD DEMO) | ItchIo | Top Hat Studios, Inc. | | |
| Sense - 不祥的预感: A Cyberpunk Ghost Story | ItchIoSteam | Top Hat Studios, Inc. | | |
| Sense [Completed Pre-Alpha] | ItchIo | EagleGames | | |
| Sense of The Devil | Steam | | | |
| Sense: A Cyberpunk Ghost Story | Switch | Suzaku | Top Hat Studios | |
| Senseless | ItchIo | Sven AhlgrimmFearful Team | | |
| Senseless Bloodbath - Unfair FPSC Game | ItchIo | masterkeef | | |
| Senshi Tank 2: Space Bots | Steam | | | |
| Sensible Blood Rugby | Steam | | | |
| Sensible Golf | DOSWindows | Sensible Software | Virgin Interactive EntertainmentVirgin Interactive | |
| Sensible Soccer | DOSGameGearMasterSystemPS1 | Sensible SoftwareEurocomKrisalis Software | Sensible SoftwareSony ImagesoftGT Interactive | |
| Sensible Soccer '98 | DOSWindows | Sensible Software | GT Interactive | |
| Sensible Soccer 2006 | PS2WindowsXBOX | Kuju EntertainmentKuju Sheffield | Codemasters | |
| Sensible Soccer: European Champions | AmigaCD32GBSegaGenesis | Apache SoftwareSensible Software | Renegade SoftwareSony Imagesoft | |
| Sensible Soccer: European Champions - •Championship Soccer '94NA | SNES | Sensible Software | Sony Imagesoft | |
| Sensible Soccer: European Champions: 92/93 Edition | DOS | Sensible Software | Renegade Software | |
| Sensible Soccer: International Edition | AmigaCD32 | Apache Software | Renegade Software | |
| Sensible World of Soccer | DOS | Sensible Software | Renegade Software | |
| Sensible World of Soccer (SWOS) | XBOX360 | Kuju Entertainment | Codemasters | |
| Sensible World of Soccer 95-96 | DOS | Sensible Software | Sensible Software | |
| Sensible World of Soccer 96-97 | DOS | Sensible Software | Renegade Software | |
| Sensible World of Soccer: European Championship Edition | DOS | Sensible Software | Renegade Software | |
| SensibleGear | ItchIo | looneybits | | |
| Sensitive Hearts Club | ItchIo | banh mi | | |
| Sensorium | Steam | | | |
| Sensory Leakage [demo] | ItchIo | Garrick | | |
| Sensual Adventures - Episode 5 | Steam | | | |
| Sensual Adventures - The Game | Steam | | | |
| Sensual VR | Steam | | | |
| Sent to Die | ItchIo | Ajey Pandey | | |
| Sent, 9:23 AM | ItchIo | Dovahbilly | | |
| Sentence Scramble | ItchIo | Making English Fun | | |
| Sentenced | Steam | | | |
| Sentience | Steam | | | |
| Sentience: The Android's Tale | Steam | | | |
| Sentient | DOSPS1Windows | Psygnosis | Psygnosis | |
| Sentient Freedom | ItchIo | LuTDC | | |
| Sentimental Graffiti | PS1SegaSaturn | NEC InterchannelMarcusCybelleComix | NEC Interchannel | |
| Sentimental Graffiti 2 | Dreamcast | NEC Interchannel | NEC Interchannel | |
| Sentimental Graffiti: Yakusoko | PS1 | NEC Interchannel | NEC Interchannel | |
| Sentimental Graffiti: Yakusoku | Dreamcast | NEC Interchannel | NEC Interchannel | |
| Sentimental Journey | PS1 | Banpresto | Banpresto | |
| Sentimental K | Steam | | | |
| Sentimental Prelude | PS2 | Interchannel | Interchannel | |
| Sentimental Trickster: Yaoi BL Gay Visual Novel | Steam | | | |
| Sentimental Wake | ItchIo | jujule | | |
| Sentiments Enneigés [Short, EN, FR] | ItchIo | Nighten | | |
| Sentimentum | ItchIo | Thomas Ling | | |
| Sentinel | Atari7800ItchIoSteam | ImagineeringSantima Games | Atari Corporation | |
| Sentinel - Holiday Special | ItchIo | nyehilism | | |
| Sentinel 3: Homeworld | Steam | | | |
| Sentinel 4: Dark Star | Steam | | | |
| Sentinel Returns | PS1Windows | PsygnosisHookstone | Hookstone ProductionsPsygnosis | |
| Sentinel Worlds I: Future Magic | DOS | Binary SystemsElectronic Arts | Electronic Arts | |
| Sentinel Zero | ItchIo | JumpmenGaming | | |
| Sentinel, The | AmstradCPCDOSZXSpectrum | Geoff CrammondSoftware Creations (Mike Follin, Geoff Crammond, Tim Follin) | Firebird Software | |
| Sentinel: Cursed Knight | Steam | | | |
| Sentinels | Steam | | | |
| Sentinels of Freedom | Steam | | | |
| Sentinels of the Multiverse | Steam | | | |
| Sento Stream | Steam | | | |
| Sentou Gakuen: Revival | Steam | | | |
| Sentou Kokka Kai Improved | PS1 | Marionette | SCEI | |
| Sentou Kokka Kai: Legend | PS2 | Opera House | Soliton | |
| Sentou Kokka Kai: New Operations | PS2 | Kadokawa Games | Kadokawa Games | |
| Sentou Kokka: Air Land Battle | PS1 | Marionette | SCEI | |
| Sentou Mecha Xabungle: The Racing Action | PS1 | Access | Bandai | |
| Sentou Yousei Yukikaze: Yousei no Mau Sora | XBOX | Aquasystem | Aquasystem | |
| Sentouin: Yamada Hajime | GBA | Rokumendo | Kids Station | |
| Sentris | ItchIoSteam | Timbre Interactive | | |
| Sentry | ItchIo | monkeyzav | | |
| Sentry Knight Tactics | Steam | | | |
| SentySanta | ItchIo | Ido Adler | | |
| Senza Peso | Steam | | | |
| Sep's Diner | Steam | | | |
| Sep's Diner (Oculus Quest) | ItchIo | Scale-1 Portal | | |
| Separate Hearts | PS2 | KID | KID | |
| Separated | ItchIo | Danial Jumagaliyev | | |
| Sephirothic Stories | SteamXboxOne | Exe Create | Kemco | |
| Sepia Tears | ItchIoSteam | Scarlet String Studios | | |
| Sepia Tears: Reprise Edition | ItchIo | Scarlet String Studios | | |
| Sepia and the Magical Book | ItchIo | konoe | | |
| Seppo VS Goblins | ItchIo | Feilkin | | |
| Sepsis | ItchIo | Grame Studios | | |
| Sept jours, sept lieux, sept vies | Steam | | | |
| September 1st | ItchIo | Rémi Töötätä | | |
| September Harvest | ItchIo | tyedye105 | | |
| September is halfway over | ItchIo | Adam Le Doux | | |
| Septentrion: Out of the Blue | PS1 | Human Entertainment | Human Entertainment | |
| Septerra Core | Steam | | | |
| Septerra Core: Legacy of the Creator | Windows | Valkyrie Studios | Monolith Productions | |
| Septic Savages | Steam | | | |
| Sepulcri | AmstradCPC | | Reaktör | |
| Seq-O-Ban | ItchIo | Marcos Donnantuoni | | |
| Seqic 2.0 - Experimental Music Sequencer | ItchIo | Fascinating Earthbound Objects | | |
| Sequel Studios | ItchIo | SystemLogoff | | |
| Sequence (2019) | ItchIo | David King Made Some Games | | |
| Sequence Break (Demo) | ItchIo | No Extra Lives | | |
| Sequence8 | ItchIo | billiam | | |
| Sequence: Chapter 1 | ItchIo | Brendan Lehman | | |
| Sequoia | ItchIo | Jhu | | |
| Serafina's Crown | ItchIoSteam | Woodsy Studio | | |
| Serafina's Saga | ItchIo | Woodsy Studio | | |
| Seraph | Steam | | | |
| Seraphica | ItchIo | DragonLilly | | |
| Seraphims of Astraeus | Steam | | | |
| Seratonin Style | ItchIo | the 27th realest man | | |
| SereNest | Steam | | | |
| Serena | ItchIoSteam | UltraVioletGames | | |
| Serenade of the Sirens | ItchIoSteam | Chukobyte | | |
| Serenity | ItchIo | NykTV | | |
| Serenity VR | ItchIo | Kaveh Tabar | | |
| Serenity at Dusk | ItchIo | klaiis | | |
| Serf City: Life is Feudal | DOS | Blue Byte | Blue Byte | |
| Serfs | ItchIo | K2software | | |
| Serfs Galore | ItchIo | Croxel Studios | | |
| Sergeant Duffy and the Kidnapped Scientist | DOS | Jeremy Thielen | | |
| Sergeant Seymour Robot Cop | ZXSpectrum | Big Red Software (David Spicer, Jason Brashill, Allister Brimble) | Codemasters | |
| Sergeant Seymour Robotcop | AmstradCPC | | Codemasters | |
| Serial Cleaner | SteamSwitchXboxOne | iFun4alliFun4All | Curve Digital | |
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