| | Name | Platforms | Developer | Publisher | |
|---|
| Servant | ItchIo | Diel Mormac | | |
| Servant of the Red Goddess | ItchIo | MorpheusKitami | | |
| Servants | ItchIo | Thomas Olsson | | |
| Serve & Volley | DOS | Artech Digital Entertainments | Accolade, Inc. | |
| Serve With Dipping Sauce | ItchIo | Juliayw | | |
| Serve the C.U.B.E | ItchIo | Jarrodmclagit | | |
| Served! | Steam | | | |
| Server Keeper | ItchIo | thetego | | |
| Server Mirroring | ItchIo | Klinker | | |
| Server is Down | Steam | | | |
| Service Bots | ItchIo | BoingThe2nd | | |
| Service Disruptions | ItchIo | ducklingsmith | | |
| Sesame Street Sports | GBCPS1 | Bonsai Entertainment CorporationChildren's Television Workshop | NewKidCo NAUbi Soft EUNewKidCo | |
| Sesame Street: 1-2-3 | NES | Zippo Games | Hi Tech Expressions | |
| Sesame Street: A-B-C | NES | Zippo Games | Hi Tech Expressions | |
| Sesame Street: A-B-C/1-2-3 | NES | Zippo Games | Hi Tech Expressions | |
| Sesame Street: Alphabet Avenue | SegaPico | Appaloosa Interactive | Sega | |
| Sesame Street: Big Bird's Hide & Speak | NES | Riedel Software Productions | Hi Tech Expressions | |
| Sesame Street: Cookie's Counting Carnival | Wii | Black Lantern Studios | Warner Bros. Interactive Entertainment | |
| Sesame Street: Countdown | NES | Riedel Software Productions | Hi Tech Expressions | |
| Sesame Street: Counting Cafe | SegaGenesis | Electronic Arts | Electronic Arts | |
| Sesame Street: Elmo's 123s | GBC | Bonsai Entertainment Corporation | NewKidCo NAUbi Soft EU | |
| Sesame Street: Elmo's A-to-Zoo Adventure | Wii | Black Lantern Studios | Warner Bros. Interactive Entertainment | |
| Sesame Street: Elmo's ABCs | GBC | Bonsai Entertainment Corporation | NewKidCo NAUbi Soft EU | |
| Sesame Street: Elmo's Letter Adventure | PS1 | Children's Television Workshop | NewKidCo | |
| Sesame Street: Elmo's Musical Monsterpiece | Wii | Griptonite Games | Warner Bros. Interactive Entertainment | |
| Sesame Street: Elmo's Number Journey | PS1 | Children's Television Workshop | NewKidCo | |
| Sesame Street: Once Upon a Monster | XBOX360 | Double Fine Productions | Warner Bros. Interactive Entertainment | |
| Sesame Street: Ready, Set, Grover! | Wii | Griptonite Games | Warner Bros. Interactive Entertainment | |
| Sesame Street: The Adventures of Elmo in Grouchland | GBC | Bonsai Entertainment Corporation | NewKidCo NAUbi Soft EU | |
| Session | WindowsXboxOne | crea-ture StudiosCreature Studios | crea-ture StudiosCreature Studios | |
| Session Seven | ItchIoSteam | SessionSevenGame | | |
| Session Zero - Version Française | ItchIo | Volonté | | |
| Session: Skateboarding Sim Game | Steam | | | |
| SessizOl! | ItchIo | DeathYigit | | |
| Set Café | Steam | | | |
| Set Us Up The Bomb | ItchIo | CovalentBonds | | |
| Set for the Battle | Steam | | | |
| Seth's Escape! | ItchIo | AntiqueGearGames | | |
| Sethian | ItchIoSteam | Duang! Games, LLC | | |
| Setmind Cup 2020 MiguelVeludo=super bode | ItchIo | miguel.veludo | | |
| Setsujū: Yuganda Kioku | FMTownsX68000 | JAST | JAST | |
| Settings: The Game | ItchIo | Massi | | |
| Settled | Steam | | | |
| Settlement Zero | Steam | | | |
| Settler (CCA) | ItchIo | Project Springbok at CCA | | |
| Settler 7DRL 2017 | ItchIo | TheBroomInstitute | | |
| Settler's Dawn | ItchIo | RyanGameDev | | |
| Settlers 7: Paths to a Kingdom | Windows | Blue Byte | Ubisoft | |
| Settlers II (Gold Edition) | DOS | Blue Byte | Blue Byte | |
| Settlers II: Veni, Vidi, Vici | DOS | Blue Byte | Blue Byte | |
| Settlers of Albion | ItchIo | Fabletale | | |
| Settlers of Orion | Steam | | | |
| Settlers of the Deep | ItchIo | giann | | |
| Settlers, The | DOS | Blue Byte | Blue Byte | |
| Setup Developer Tool 2018 | Steam | | | |
| Seul (Alone): The entrée | Steam | | | |
| Seul. (Alone) the day before | ItchIo | Paranormal Games | | |
| Seul.(Alone): The entrée | ItchIo | Paranormal Games | | |
| Seum: Speedrunners from Hell | XboxOne | Pine Studio | Headup Games | |
| Seussian Procedural Tree Creator | ItchIo | rednax | | |
| Sev - Sev's Nightmare | ItchIo | ARStudio | | |
| Sev das Horror Spiel | ItchIo | FreeRoamGames | | |
| Seven + 11 | ItchIo | Low-Uri | | |
| Seven Bullets Zombie Apocalypse | Steam | | | |
| Seven Cities of Gold Commemorative Edition | DOS | Interactive Designs | Electronic Arts | |
| Seven Cities of Gold, The | DOS | Ozark Softscape | Electronic Arts | |
| Seven Days | Steam | | | |
| Seven Days in Purgatory | ItchIo | kypello | | |
| Seven Demons | Steam | | | |
| Seven Doors | ItchIoSteam | Indigo Studios | | |
| Seven Doorways | ItchIo | Graeme Borland | | |
| Seven Dunes: Curse on the Golden Sand | Steam | | | |
| Seven Horns From Tilt | Steam | | | |
| Seven Kingdoms 2 HD | Steam | | | |
| Seven Kingdoms II: The Fryhtan Wars | Windows | Enlight | Ubisoft | |
| Seven Kingdoms: Ancient Adversaries | Steam | | | |
| Seven Knights: Time Wanderer | Switch | Netmarble | Netmarble | |
| Seven Mysteries | ItchIo | Sang Hendrix | | |
| Seven Mysteries: The Last Page | ItchIoSteam | Sang Hendrix | | |
| Seven Nations | Steam | | | |
| Seven Photos: Photographic Detective Murder Mystery Game Inspired by DanganRonpa | ItchIo | chibixi | | |
| Seven Red Lines | Steam | | | |
| Seven Sages | ItchIo | GhostFromTheVoid | | |
| Seven Samurai 20XX | PS2 | Dimps | Sammy StudiosJP,NAYBM SisaKOSegaEU | |
| Seven Samurai RL (7SRL) (7DRL) | ItchIo | benhem | | |
| Seven Scrolls | ItchIo | Venbrux | | |
| Seven Seas Solitaire | Steam | | | |
| Seven Second Samurai | ItchIo | jerryardo | | |
| Seven Second Sandwich Simulator | ItchIo | Lakupo | | |
| Seven Simple Wonders | ItchIo | Candal | | |
| Seven Sins - Academic Version | Steam | | | |
| Seven Spirits of Ra, The | DOS | | Sir-Tech | |
| Seven Weeks of Cat Monarchy | ItchIo | Cat Night | | |
| Seven Wonders of St. Clementine | Steam | | | |
| Seven days with the Ghost | Steam | | | |
| Seven for a Secret | ItchIo | bisente | | |
| Seven: Enhanced Edition | Steam | | | |
| Seven: Molmorth no Kiheitai | PS2 | Namco | Namco | |
| Seven: Reboot | Steam | | | |
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