| | Name | Platforms | Developer | Publisher | |
|---|
| Sega Ninja (titre alternatif: Ninja PrincessJP) | Arcade | | Sega | |
| Sega Rally 2 | ArcadeWindows | AM5 | Sega | |
| Sega Rally 2006 | PS2 | Sega | Sega | |
| Sega Rally Championship | ArcadeGBANgageSegaSaturnWindows | DiceHitmakerSega AM3AM5 | Sega | |
| Sega Rally Championship 2 | Dreamcast | Sega AM3 | Sega | |
| Sega Rally Online Arcade | PS3XBOX360 | Sega | Sega | |
| Sega Rally Revo | PS3WindowsXBOX360 | Sega Racing StudioSEGA Racing Studio | Sega | |
| Sega Saturn de Hakken''!! Tamagotchi Park | SegaSaturn | Ancient | Bandai | |
| Sega Smash Pack | GBAWindows | CodeFireSega | THQSega | |
| Sega Smash Pack 2 | Windows | Sega | Sega | |
| Sega Smash Pack Vol. 1 | Dreamcast | Sega | Sega | |
| Sega Soccer Slam | GamecubePS2XBOX | Black Box Games | Sega | |
| Sega Sports Tennis - •Virtua Tennis 2EU - •Power Smash 2JP | PS2 | Hitmaker | Sega | |
| Sega Superstars | PS2 | Sonic Team | Sega | |
| Sega Superstars Tennis | DSPS2PS3WiiXBOX360 | Sumo Digital | Sega | |
| Sega Swirl | Dreamcast | Tremor Entertainment | Sega | |
| Sega Tetris | Dreamcast | Wow Entertainment | Sega | |
| Sega Touring Car Championship | ArcadeSegaSaturnWindows | Sega AM3Sega-AM3 | Sega | |
| Sega Vintage Collection: Alex Kidd & Co. - (Alex Kidd in Miracle World, Super Hang-On, The Revenge of Shinobi) | XBOX360 | SegaM2 | Sega | |
| Sega Vintage Collection: Golden Axe - (Golden Axe, II, III) | XBOX360 | SegaM2 | Sega | |
| Sega Vintage Collection: Monster World - (Wonder Boy in Monster Land, Wonder Boy in Monster World, Monster World IV) | XBOX360 | SegaM2 | Sega | |
| Sega Vintage Collection: Streets of Rage - (Streets of Rage, 2, 3) | XBOX360 | SegaM2 | Sega | |
| Sega Vintage Collection: ToeJam & Earl - (ToeJam & Earl, Panic on Funkotron) | XBOX360 | SegaM2 | Sega | |
| Sega World Tournament Golf | MasterSystem | Sega | Sega | |
| Sega Worldwide Soccer '97 | SegaSaturnWindows | Sega | Sega | |
| Sega Worldwide Soccer '98 | SegaSaturn | Sega | Sega | |
| Sega Worldwide Soccer 2000 | Dreamcast | Sega | Sega | |
| Sega Worldwide Soccer 2000 Euro Edition | Dreamcast | Silicon Dreams | Sega | |
| SegaSonic the Hedgehog | Arcade | | Sega | |
| Segagaga | Dreamcast | Sega | Sega | |
| Segare Ijiri | PS1 | Enix | Enix | |
| Segata Sanshiro Shinkenyugi | SegaSaturn | Ecole Software | Sega | |
| Segatakai | ItchIo | Indemonai Games | | |
| Segfault[0]: Mad Hatter | ItchIo | Connor Thomas Cleary | | |
| Segmentation Fault (Alpha 0.1.5) | ItchIo | Dr. Goop | | |
| Segmentation_Fault | ItchIo | MagicEngineeringnewyear | | |
| Segmented | ItchIo | Freezex | | |
| Sei Senshi Mokkoriman | PC98 | Illusion | Illusion | |
| Sei Shōjo Sentai Lakers | PC98 | Apple Pie | Apple Pie | |
| Sei Shōjo Sentai Lakers II | PC98 | Apple Pie | Apple Pie | |
| Sei Shōjo Sentai Lakers III | PC98 | Apple Pie | Apple Pie | |
| Seicross | NES | Nichibutsu | FCI | |
| Seicross (titre alternatif: Sector ZoneJP) | Arcade | | Nichibutsu | |
| Seidkona: A Tale of Death and Dice | ItchIo | FireTotemGames | | |
| Seifuku Densetsu Pretty Fighter X | SegaSaturn | Sol | Imagineer | |
| Seifuku Densetsu: Pretty Fighter | SNES | | Imagineer Co., Ltd. | |
| Seiga Kaku uses her amazing Taoist arts and gives you a life lesson | Steam | | | |
| Seight | ItchIo | Kwixb | | |
| Seigi no Mikata | PS2 | Sony Computer Entertainment | Sony Computer Entertainment | |
| Seigneurs des royaumes | Steam | | | |
| Seijuu Maden: Beasts & Blades | SNES | | Bullet-Proof Software | |
| Seikai Risshiden: Yoi Kuni Yoi Seiji | SegaSaturn | Digitalware | BMG Japan | |
| Seikai no Monshō | PS1 | Bandai | Bandai | |
| Seikai no Senki | PS2 | Gainax | CyberFront | |
| Seiken Acho (a.k.a. Taekwon-Do, Kung-Fu Master) | MSX | | ASCII Corporation | |
| Seiken Densetsu | PC88 | Compac | Compac | |
| Seiken No Ken - Holy Sword Sword | ItchIo | RetroDEV | | |
| Seiken to Maken no Densetsu | PC98 | Login Soft | ASCII Corporation | |
| Seiken: Psycho Calibur | FamicomCD | | Imagineer | |
| Seikima II Special | MSX | | | |
| Seiko's Closet | ItchIo | Daniel Zale | | |
| Seikoku 1092: Souheiden | PS1 | Yutaka | Yutaka | |
| Sein | ItchIo | leoroura | | |
| Seinarukana -The Spirit of Eternity Sword 2- | Steam | | | |
| Seinfeld The Telltale Series | ItchIo | Big Trash Games | | |
| Seipoi Densetsu | GBC | | Gaps | |
| Seirai Hata RayBlade | Dreamcast | Winky Soft | Winky Soft | |
| Seirei | Steam | | | |
| Seirei Hata RayBlade | PS1 | Winkysoft | Winkysoft | |
| Seirei Senshi Spriggan | PCEngine | | Naxat Soft | |
| Seirei Shoukan: Princess of Darkness | PS1 | Shoeisha | Shoeisha | |
| Seiryū Densetsu Monbit | PCEngine | | Hudson Soft | |
| Seisenshi Denshō | PCEngine | | Nihon Bussan | |
| Seishin - Virtual Rhythm | Steam | | | |
| Seishoujo Kantai Virgin Fleet | PS1 | Konami | Konami | |
| Seismic Planet | ItchIo | Jess | | |
| Seiso Master KEN | Steam | | | |
| Seiya Monogatari | PCEngine | | Hudson Soft | |
| Seize The Clay | ItchIo | Second Dimension Games | | |
| Seize-it | ItchIo | lefthandexodia | | |
| Sekai Fushigi Hakken! Troya | Dreamcast | NEC Interchannel | Sega | |
| Sekai Meisaku Gekijou | SegaPico | Sega | Sega | |
| Sekai Saikyou Ginsei Igo | PS1 | I.Magic | I.Magic | |
| Sekai Saikyou Ginsei Igo 2 | PS1 | I.Magic | I.Magic | |
| Sekai Saikyou Ginsei Igo 3 | PS1 | I'Max | I'Max | |
| Sekai Saikyou Ginsei Igo 5 | PS2 | Magnolia | Magnolia | |
| Sekai Saikyou Ginsei Igo 6 | PS2 | Magnolia | Magnolia | |
| Sekai Saikyou Ginsei Igo Kouza | PS2 | SilverStar | SilverStar | |
| Sekai Saikyou Ginsei Igo: Hybrid Monte Carlo | PS3 | SilverStar | | |
| Sekai Saikyou Ginsei Shogi | PS1 | I'Max | I'Max | |
| Sekai Saikyou Ginsei Shogi: Fuuum Ryouko Raiden | PS3 | SilverStar | | |
| Sekai de Ichiban Kimi ga Suki! | X68000 | Cocktail Soft | FairyTale | |
| Sekai no Subete: Two of Us | PS2 | Yeti | Yeti | |
| Sekigahara | FMTownsPCEngine | Artdink | ArtdinkTonkin House | |
| Sekirei: Mirai Kara no Okurimono | PS2 | Alchemist | Alchemist | |
| Sekiro: Shadows Die Twice | XboxOne | FromSoftware | Activision | |
| Sekiro™: Shadows Die Twice - GOTY Edition | Steam | | | |
| Selatria: Advent of the Dakk'rian Empire | Steam | | | |
| SelectelJam | ItchIo | bitachdev | | |
| Selection I & II: Erabareshi Mono & Ankoku no Fuuin | GB | | Kemco | |
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