| Synergistic | Developer | |
| Synergistic Software | DeveloperPublisher | |
| Synergistic Software, Inc. | Developer | |
| Synergistic Solar | Publisher | |
| Synergy | Publisher | |
| Synergy (Andrew Severn, Peter Austin, Sonic Graffiti, Tau Zero) | Developer | |
| Synergy (Charles Goodwin) | Developer | |
| Synergy Inc. | DeveloperPublisher | |
| Synergy Interactive | Publisher | |
| Synergy Interactive Crop. | Publisher | |
| Synergy Studios | Developer | |
| Synergy's Forge | Developer | |
| Synergy, Inc. | DeveloperPublisher | |
| Synergy-moe | Developer | |
| Synetic | DeveloperPublisher | |
| Synfoniz | Developer | |
| Syngelsa | Developer | |
| Synokoria | Developer | |
| Synset Games | Developer | |
| SynthOveride | Developer | |
| SyntheOtaku | Developer | |
| Syntheon | Developer | |
| Synthetic Dimensions | Developer | |
| Syoudre | Developer | |
| Sypher | Developer | |
| Syphisprod | Developer | |
| Syphonx | Developer | |
| SyrStudios | Developer | |
| Syringa Vulgaris | Developer | |
| Syriph | Developer | |
| Syrox Developments | DeveloperPublisher | |
| Syrrann | Developer | |
| Syrup Pirates | Developer | |
| Syrus Turner | Developer | |
| Syscom | DeveloperPublisher | |
| Syscom Entertainment | Developer | |
| Syscom EntertainmentJP | Publisher | |
| Syscom JP | Publisher | |
| SyscomJP | Publisher | |
| Sysoft | Developer | |
| System 3 | DeveloperPublisher | |
| System 3 (EU) | Publisher | |
| System 3 Software | DeveloperPublisher | |
| System 3EU | Publisher | |
| System 3PAL | Publisher | |
| System 4 | Publisher | |
| System 4 Software | Publisher | |
| System Applied Technology | Developer | |
| System Create | DeveloperPublisher | |
| System Era Softworks | DeveloperPublisher | |