| StudioDaeera | Developer | |
| StudioFG | DeveloperPublisher | |
| StudioMDHR | DeveloperPublisher | |
| StudioPoncho | Developer | |
| StudioSenpai | Developer | |
| StudioThunderbolt | Developer | |
| StudioVR | Developer | |
| StudioVorfall | Developer | |
| Studionum43 | Developer | |
| Studios Ch'in | Developer | |
| Studios Spero | Developer | |
| StudyMan99 | Developer | |
| StuffandThangs | Developer | |
| Stuffduck Software (The Shaw Brothers) | Developer | |
| Stuffed Wombat | Developer | |
| Stuffman | Developer | |
| StumpCricket | Developer | |
| Stumphead Games | Developer | |
| Stunlock Studios | DeveloperPublisher | |
| StunningGaming | Developer | |
| Stunt Puppy Entertainment | Developer | |
| StupidPawn | Developer | |
| Stupidipixel | Developer | |
| Stupidplusplus | Developer | |
| Stusse Games | Developer | |
| StyleKing | Developer | |
| Styrax | Developer | |
| StyrofoamBoots | Developer | |
| Stywox | Developer | |
| Stéphane F. | Developer | |
| Stéphane Picq | Developer | |
| Su Kızılağaç | Developer | |
| Su4enka | Developer | |
| SuBiScript | Developer | |
| SubLOGIC | Publisher | |
| SubSystemD | Developer | |
| SubZero Software | Developer | |
| SubZtep | Developer | |
| Subak | Developer | |
| Subak Soda Studios | Developer | |
| Subdued Software | Developer | |
| Subfrost Interactive | Developer | |
| Subhamoy Biswas | Developer | |
| Subliminal Games | Developer | |
| Sublogic | DeveloperPublisher | |
| Subsage | Developer | |
| Subset Games | DeveloperPublisher | |
| Subsino | Publisher | |
| Subsoap | Developer | |
| Substudios | Developer | |