| SpinVector | Developer | |
| Spina | Developer | |
| SpindleyQ | Developer | |
| Spinfoam Games | Developer | |
| Spinnaker | Developer | |
| Spinnaker Software | DeveloperPublisher | |
| Spinnaker Software Corporation | DeveloperPublisher | |
| Spinning Coin | Developer | |
| Spinning Punch Studios | Developer | |
| Spiral (Jose Antonio Acedo) | Developer | |
| Spiral Atlas | Developer | |
| Spiral House | Developer | |
| Spiral Summit Games | Developer | |
| SpiralPuzzle | Developer | |
| Spire Interactive | Developer | |
| Spirit Stone Studio | Developer | |
| Spirit of Discovery | Publisher | |
| Spirit of Discovery (Game developers) | Developer | |
| Spirit.creations | Developer | |
| SpitBlaze | Developer | |
| SpitefulFox | Developer | |
| Spitko | Developer | |
| Spius | Developer | |
| Spiyon465 | Developer | |
| Splash (video game company) | Publisher | |
| Splash Damage | Developer | |
| SplashTeam | Developer | |
| Splashcats | Developer | |
| Splashteam | Developer | |
| Spleeen | Developer | |
| Spleen Machine | Developer | |
| SplendidAutomaton | Developer | |
| SplendidDog | Developer | |
| Splendy Games | Developer | |
| Splerp | Developer | |
| Splickety | Developer | |
| Splinter Vision | Developer | |
| Split | Developer | |
| Split82 | Developer | |
| SplitHare | Developer | |
| Splixun | Developer | |
| Splodey | Developer | |
| Splumsy | Developer | |
| Spoland | Developer | |
| Spolity Default | Developer | |
| Spongey Kitty | Developer | |
| Sponny Bard Productions | Developer | |
| SpoocleMacBoogle | Developer | |
| SpookifyDev | Developer | |
| Spooklight Games | Developer | |