| SpaceTruckerGames | Developer | |
| SpaceUkulele | Developer | |
| SpaceWedgieLLC | Developer | |
| SpaceZeta | Developer | |
| Spaceboy | Developer | |
| Spaceboy00 | Developer | |
| Spacecastles Unlimited | Developer | |
| SpacefaceDEV | Developer | |
| Spacefriend | Developer | |
| Spaceman Ltd (Sandy White, Angela Sutherland) | Developer | |
| Spacemarine9 | Developer | |
| Spacemyname | Developer | |
| Spaces of Play | DeveloperPublisher | |
| Spacetronaut | Developer | |
| Spacewave Software | Developer | |
| Spaceways | DeveloperPublisher | |
| SpacialPumpkin Studios | Developer | |
| SpadXIII | Developer | |
| Spafuji | Developer | |
| SpaghettiLord1010 | Developer | |
| Spalato Bros | Developer | |
| Spalt(er) | Developer | |
| SpaneDev | Developer | |
| Spannerworx | Developer | |
| Sparckman | Developer | |
| SpareWizard | Developer | |
| Spark Creative | Developer | |
| Spark Unlimited | Developer | |
| Sparklin Labs | Developer | |
| SparklyRainbows | Developer | |
| Sparks Games | Developer | |
| Sparky99 | Developer | |
| Sparpweed | DeveloperPublisher | |
| Sparrow in the field | Developer | |
| Sparrowspell | Developer | |
| Spartan Game Labs | Developer | |
| Spartan717 | Developer | |
| SpartanFanDMD | Developer | |
| SpartanPG | Developer | |
| Spassfabrik | Developer | |
| Spatula Interactive Ltd. | Developer | |
| Spawn Point | Developer | |
| SpawnCampGames | Developer | |
| Spawny Toorte | Developer | |
| Speakeasy Development | Developer | |
| Spearhead Games | DeveloperPublisher | |
| Spearmints | Developer | |
| Special FX | Developer | |
| Special FX Software | Developer | |
| Special FX Software (James Bagley, Charles Davies, Keith Tinman) | Developer | |