| Silicon & Synapse | Developer | |
| Silicon Beach Software | Developer | |
| Silicon Dreams | Developer | |
| Silicon Dreams Studio | Developer | |
| Silicon Galaxy | Developer | |
| Silicon Ice Development | Developer | |
| Silicon Joy | Publisher | |
| Silicon Knights | DeveloperPublisher | |
| Silicon Software | Developer | |
| Silicon Sorcery | Developer | |
| Silicon Studio | Developer | |
| SiliconWorx | Developer | |
| Silivar | Developer | |
| Silk | Developer | |
| Silken Sail Entertainment | Developer | |
| SilkevdSmissen | Developer | |
| Silkworm Sweatshop | Developer | |
| Silky Smooth Studio | Developer | |
| Silky's | DeveloperPublisher | |
| SillikOne | Developer | |
| SillyGame | Developer | |
| SillyGlassBoy | Developer | |
| Sillysoft Games | DeveloperPublisher | |
| Silmarils | DeveloperPublisher | |
| Silmarils Software | Publisher | |
| Siltocyn | Developer | |
| Silvarc | Developer | |
| Silver Cow Studio | DeveloperPublisher | |
| Silver Creek Entertainment | Developer | |
| Silver Dollar Games | DeveloperPublisher | |
| Silver Gear Interactive | Developer | |
| Silver Lemur Games | Developer | |
| Silver Lightning Software | DeveloperPublisher | |
| Silver Sphere Studios | DeveloperPublisher | |
| Silver Star | DeveloperPublisher | |
| Silver Star Japan | DeveloperPublisher | |
| Silver Style Entertainment | Developer | |
| Silver Wish Games | Developer | |
| Silver-Streak | Developer | |
| SilverBack Studios | Developer | |
| SilverBirch Studios | Developer | |
| SilverBrocks | Developer | |
| SilverBullet | Developer | |
| SilverHyena | Developer | |
| SilverLine Software | Publisher | |
| SilverLining | Developer | |
| SilverSnakeGameS | Developer | |
| SilverStar | DeveloperPublisher | |
| SilverStarJapan | Developer | |
| SilverTabbyCat ~ Visual Novel Games | Developer | |