| Selavi Games | Developer | |
| Seldon | Developer | |
| Selectricity Productions | Developer | |
| Selectsoft | Publisher | |
| Selectsoft Publishing | Publisher | |
| Selen | DeveloperPublisher | |
| SelenJP | DeveloperPublisher | |
| SeleneVirus | Developer | |
| Selenity | Developer | |
| Selexy | Developer | |
| Self | Publisher | |
| Self Made Miracle | Developer | |
| Self-published | Publisher | |
| SelfPC | Developer | |
| Selfish Dream | Developer | |
| Selina | Developer | |
| Selkcip | Developer | |
| Seltzy | Developer | |
| Selvysus | Developer | |
| Selwes | Developer | |
| SemLaan | Developer | |
| Semaeopus | Developer | |
| Semag Games | Developer | |
| Semaphore | Developer | |
| Semenar | Developer | |
| SemiCom | Publisher | |
| SemiSinful | Developer | |
| Semicolon42 | Developer | |
| Semicom | Publisher | |
| Semisoft | Developer | |
| SemiteCoding | Developer | |
| Semmelknoedelstampfer | Developer | |
| SempiternityGMS | Developer | |
| Sen | Developer | |
| SenadMMG | Developer | |
| Senekagames | Developer | |
| Sengaya Games | Developer | |
| Senior Salvador | Developer | |
| Senior-X | Developer | |
| Sennari Interactive | Developer | |
| Sennin | Developer | |
| Sense Games | Developer | |
| Sense_101 | Developer | |
| SenseiSquishy | Developer | |
| Sensen Games | Developer | |
| Sensible Software | DeveloperPublisher | |
| Sensible Software (Richard Joseph) | Developer | |
| Sensory Sweep | Developer | |
| Sensory Sweep Studios | Developer | |
| Sensui Software | Developer | |