| Schrodinger Games | Developer | |
| Schtarr | Developer | |
| Schu | Developer | |
| Schwartzanthonyj | Developer | |
| Schwein Studios | Developer | |
| Schwender.exe | Developer | |
| Schwer | Developer | |
| Sci Entertainment | Publisher | |
| Sci-Fi Adventure Game | Developer | |
| Sci-Nimations | Developer | |
| Sciaenops | Developer | |
| Sciaracastro | Developer | |
| Science House | Publisher | |
| ScienceJ | Developer | |
| SciencePixelGames | Developer | |
| Scienitive | Developer | |
| Scientifically Proven | Developer | |
| Scientifically Proven Entertainment | Developer | |
| ScientistWD | Developer | |
| Sciman101 | Developer | |
| ScimitarDD | Developer | |
| Scio Co. | Developer | |
| Scipio Software | Developer | |
| Scitron & Art | Developer | |
| Scitron & Art. | Developer | |
| Scodegames | Developer | |
| Scole Dev | Developer | |
| Scolondev | Developer | |
| ScoobyDrewAu | Developer | |
| Scoop Software Productions | DeveloperPublisher | |
| Scoot-o-Speed-Studios | Developer | |
| Scootarooni | Developer | |
| Scootch | Developer | |
| Scope Creep Studios | Developer | |
| Score Studios | Developer | |
| Score Studios LLC | Developer | |
| Scorpion 37 | Developer | |
| Scorpion Games | Developer | |
| Scorpion Soft | Publisher | |
| ScorpionRex6448(Souhail) | Developer | |
| Scorplings | Developer | |
| Scotaire | Developer | |
| ScotchCollege | Developer | |
| Scott | Developer | |
| Scott Adams | Developer | |
| Scott Adams & Alexis Adams | Developer | |
| Scott Bryan | Developer | |
| Scott Cawthon | Developer | |
| Scott Christie and Ian Gilmour | Developer | |
| Scott Doxey | Developer | |