| SpinVector | Developer | |
| Spina | Developer | |
| SpindleyQ | Developer | |
| Spinfoam Games | Developer | |
| Spinnaker | Developer | |
| Spinnaker Software | DeveloperPublisher | |
| Spinnaker Software Corporation | DeveloperPublisher | |
| Spinning Coin | Developer | |
| Spinning Punch Studios | Developer | |
| Spiral (Jose Antonio Acedo) | Developer | |
| Spiral Atlas | Developer | |
| Spiral House | Developer | |
| Spiral Summit Games | Developer | |
| SpiralPuzzle | Developer | |
| Spire Interactive | Developer | |
| Spirit Stone Studio | Developer | |
| Spirit of Discovery | Publisher | |
| Spirit of Discovery (Game developers) | Developer | |
| Spirit.creations | Developer | |
| SpitBlaze | Developer | |
| SpitefulFox | Developer | |
| Spitko | Developer | |
| Spius | Developer | |
| Spiyon465 | Developer | |
| Splash (video game company) | Publisher | |
| Splash Damage | Developer | |
| SplashTeam | Developer | |
| Splashcats | Developer | |
| Splashteam | Developer | |
| Spleeen | Developer | |
| Spleen Machine | Developer | |
| SplendidAutomaton | Developer | |
| SplendidDog | Developer | |
| Splendy Games | Developer | |
| Splerp | Developer | |
| Splickety | Developer | |
| Splinter Vision | Developer | |
| Split | Developer | |
| Split82 | Developer | |
| SplitHare | Developer | |
| Splixun | Developer | |
| Splodey | Developer | |
| Splumsy | Developer | |
| Spoland | Developer | |
| Spolity Default | Developer | |
| Spongey Kitty | Developer | |
| Sponny Bard Productions | Developer | |
| SpoocleMacBoogle | Developer | |
| SpookifyDev | Developer | |
| Spooklight Games | Developer | |
| Spookto | Developer | |
| Spooky Cat | Developer | |
| Spooky Cookie Games | Developer | |
| Spooky Doorway | DeveloperPublisher | |
| Spooky Games | Developer | |
| Spooky Squid Games Inc. | Developer | |
| SpookyAl | Developer | |
| SpookyBee | Developer | |
| SpookyBunsGames | Developer | |
| SpookySlaughtumn | Developer | |
| SpookyTanookie | Developer | |
| Spookybot | Developer | |
| SpoonProduction36 | Developer | |
| Spoonbox Studio | Developer | |
| Spoonman Games | Developer | |
| Spoony Bard Productions | Developer | |
| SportTime | DeveloperPublisher | |
| Sports Director Limited | Developer | |
| Sports Interactive | Developer | |
| Sportshorts | Developer | |
| Sportsmaster | Publisher | |
| Spotlight Software | Publisher | |
| Spotlightor Interactive | Developer | |
| Spotted Shark Studios | DeveloperPublisher | |
| Spotted Zebra | Developer | |
| Spottedphyre | Developer | |
| Spotty Doggy and Witty Doggy | Developer | |
| Sprakelsoft | DeveloperPublisher | |
| Spram | Developer | |
| Spratley | Developer | |
| Sprawl | Developer | |
| Spray | Developer | |
| Sprazzal | Developer | |
| SpreadShot | Developer | |
| Spreadable Fruit | Developer | |
| Spreadcamp | Developer | |
| Spring | Developer | |
| SpringHeeled | Developer | |
| Springarm | Developer | |
| Springboard Software | Publisher | |
| Springloaded | DeveloperPublisher | |
| Springtail | Developer | |
| SprintToTheTop | Developer | |
| Sprite | Developer | |
| SpriteQ | Developer | |
| Sprited | Developer | |
| SpritersBlock | Developer | |
| Sproing | Developer | |
| Sproing Interactive | Developer | |
| Sproing Interactive Media | Developer | |