| Special FX Software (James Bagley, Colin Rushby, Keith Tinman) | Developer | |
| Special FX Software (Jim Bagley, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Charles Davies, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Karen Davies, Tony Pomfret, Stephen Wahid) | Developer | |
| Special Projects | Developer | |
| Specialbit | Developer | |
| Specor Technology | Developer | |
| Spectacular Games | Developer | |
| Spectral Bunny Studios | Developer | |
| Spectral Dimensions | Developer | |
| Spectral Studio | Developer | |
| SpectralVisage | Developer | |
| Spectravideo | DeveloperPublisher | |
| SpectreVision | Developer | |
| Spectrem | Developer | |
| Spectris Games | Developer | |
| Spectrum Games | Publisher | |
| Spectrum Games Ltd | Publisher | |
| Spectrum HoloByte | DeveloperPublisher | |
| Spectrum HoloByte NA | Publisher | |
| Spectrum HoloByteNA | Publisher | |
| Spectrum Holobyte | DeveloperPublisher | |
| Spectrum Holobyte, Inc. | Publisher | |
| Spectrum Pacific Publishing | Publisher | |
| Speculative Simulations Ltd | Developer | |
| Speed | Developer | |
| SpeedStrip Interactive | DeveloperPublisher | |
| Speedev | Developer | |
| Speedwagon Foundation | Developer | |
| Speedy Raptors Collective | Developer | |
| SpeedyBrain | Developer | |
| Speelbaars | Developer | |
| SpektacularGames | Developer | |
| Spektor | Developer | |
| Spelkonditoriet | Developer | |
| Spelkraft | Developer | |
| Spellborn International | Developer | |
| Spellbound | Developer | |
| Spellbound Entertainment | Developer | |
| Spellbound Entertainment AG | Developer | |
| Spellbound Interactive | Developer | |
| Spellsoft | Developer | |
| Spence | Developer | |
| Spencer Alves | Developer | |
| Spencer Winson | Developer | |
| SpencerG4N | Developer | |
| Spenn | Developer | |
| Spennerino | Developer | |
| Spera_blues | Developer | |
| Sphere | Developer | |
| Sphere Inc. | Developer | |
| Sphere, Inc. | Developer | |
| Spheresoft | Developer | |
| SpherianGames | Developer | |
| Sphysics | Developer | |
| SpiRiTs | Developer | |
| Spica Studios | Developer | |
| Spice Games | Developer | |
| Spicy Ferret | Developer | |
| Spicy Gyro Games | Developer | |
| Spicy Horse | Developer | |
| Spicy Lemon | Developer | |
| Spicy Overlord | Developer | |
| Spicy Roll | Developer | |
| Spicy Tails | Developer | |
| SpicyCatGames | Developer | |
| SpicyCatStudios | Developer | |
| SpicyFrog | Developer | |
| SpicyOnTheRicey | Developer | |
| Spicyfuse | Developer | |
| Spicysoft | DeveloperPublisher | |
| Spider Lily Studios | Developer | |
| SpiderFlorist | Developer | |
| SpiderMonk Entertainment | Developer | |
| Spiderlili | Developer | |
| Spidermonk Entertainment | Developer | |
| Spiders | Developer | |
| Spidersoft | Developer | |
| Spidersoft (Gavin Wade, Chris Edwards) | Developer | |
| Spidersoft (Jonathan Court, Nick Cooke, Martin Walker, Jonathan P. Dean, C. Gibbs, R. Gill, Greame Ashton) | Developer | |
| Spiderweb Software | DeveloperPublisher | |
| Spidi | Developer | |
| Spiel | Developer | |
| Spielkind | Developer | |
| Spierek | Developer | |
| Spiffcode | Developer | |
| Spike | DeveloperPublisher | |
| Spike Chunsoft | DeveloperPublisher | |
| Spike Games | Publisher | |
| Spike JP | Publisher | |
| Spike Studio | Developer | |
| SpikeJP | Publisher | |
| SpikeJP,KO | Publisher | |
| Spikewave Games | DeveloperPublisher | |
| Spiky Games | Developer | |
| SpikySnail Games | Developer | |
| Spilim | Developer | |
| Spilt Milk Studios | Developer | |
| SpinTop Games | Developer | |