| Silicon & Synapse | Developer | |
| Silicon Beach Software | Developer | |
| Silicon Dreams | Developer | |
| Silicon Dreams Studio | Developer | |
| Silicon Galaxy | Developer | |
| Silicon Ice Development | Developer | |
| Silicon Joy | Publisher | |
| Silicon Knights | DeveloperPublisher | |
| Silicon Software | Developer | |
| Silicon Sorcery | Developer | |
| Silicon Studio | Developer | |
| SiliconWorx | Developer | |
| Silivar | Developer | |
| Silk | Developer | |
| Silken Sail Entertainment | Developer | |
| SilkevdSmissen | Developer | |
| Silkworm Sweatshop | Developer | |
| Silky Smooth Studio | Developer | |
| Silky's | DeveloperPublisher | |
| SillikOne | Developer | |
| SillyGame | Developer | |
| SillyGlassBoy | Developer | |
| Sillysoft Games | DeveloperPublisher | |
| Silmarils | DeveloperPublisher | |
| Silmarils Software | Publisher | |
| Siltocyn | Developer | |
| Silvarc | Developer | |
| Silver Cow Studio | DeveloperPublisher | |
| Silver Creek Entertainment | Developer | |
| Silver Dollar Games | DeveloperPublisher | |
| Silver Gear Interactive | Developer | |
| Silver Lemur Games | Developer | |
| Silver Lightning Software | DeveloperPublisher | |
| Silver Sphere Studios | DeveloperPublisher | |
| Silver Star | DeveloperPublisher | |
| Silver Star Japan | DeveloperPublisher | |
| Silver Style Entertainment | Developer | |
| Silver Wish Games | Developer | |
| Silver-Streak | Developer | |
| SilverBack Studios | Developer | |
| SilverBirch Studios | Developer | |
| SilverBrocks | Developer | |
| SilverBullet | Developer | |
| SilverHyena | Developer | |
| SilverLine Software | Publisher | |
| SilverLining | Developer | |
| SilverSnakeGameS | Developer | |
| SilverStar | DeveloperPublisher | |
| SilverStarJapan | Developer | |
| SilverTabbyCat ~ Visual Novel Games | Developer | |
| Silverball Studios | Developer | |
| Silverbirch Studios | Developer | |
| Silverbird | Publisher | |
| Silverbird Software | Publisher | |
| Silverm | Developer | |
| Silversober | Developer | |
| Silversoft | Publisher | |
| Silversoft Ltd | Publisher | |
| Silverstring Media | Developer | |
| Silverware Games | Developer | |
| Silvijn | Developer | |
| Silvio257 | Developer | |
| SilviuZLD | Developer | |
| Sim0wn3d | Developer | |
| SimBin | Developer | |
| SimBin Studios | DeveloperPublisher | |
| SimDevs | DeveloperPublisher | |
| SimFabric | DeveloperPublisher | |
| SimGraph | Developer | |
| SimLab Games | Developer | |
| SimSoftGames | Developer | |
| SimTex | Developer | |
| Sima | Developer | |
| Sima Games | Developer | |
| Simbi | Developer | |
| Simbin | Developer | |
| Simbiosis Interactive | Developer | |
| SimeStudios | Developer | |
| Simex | Developer | |
| Similia | Developer | |
| Similis | Developer | |
| Siminu | Developer | |
| Simis | Developer | |
| Simmer Software (Jeff Calder, George Calvert, Andy Wynd) | Developer | |
| Simo K. Tuima | Developer | |
| Simogo | DeveloperPublisher | |
| Simon & Schuster | DeveloperPublisher | |
| Simon & Schuster Interactive | DeveloperPublisher | |
| Simon 'GoZz' Mielcarek | Developer | |
| Simon Brattel | Developer | |
| Simon Butler | Developer | |
| Simon Chauvin | Developer | |
| Simon Chen | Developer | |
| Simon Cobb | Developer | |
| Simon Conway | Developer | |
| Simon Creative | Developer | |
| Simon Daniels | Developer | |
| Simon Dunstan | Developer | |
| Simon Ernst | Developer | |
| Simon Freeman | Developer | |