| Scrubby Squirrel | Developer | |
| Scruffiest Bear | Developer | |
| Scruflez | Developer | |
| Scrull | Developer | |
| Sculptured Software | DeveloperPublisher | |
| ScusX Programming | Developer | |
| Scuttlepunk | Developer | |
| ScwarfBandito | Developer | |
| Scylez | Developer | |
| Scythe Dev Team | Developer | |
| Sea Monster Media | Developer | |
| SeaDads | Developer | |
| SeaLeft Studios | Developer | |
| SeaPhoenix | Developer | |
| Seabass | Developer | |
| Seafarers Cafe | Developer | |
| Seafoam Games | Developer | |
| SealDev | Developer | |
| SealFurai | Developer | |
| Sealth94 | Developer | |
| Seamless Entertainment | Developer | |
| Seamus Ly | Developer | |
| Sean | Developer | |
| Sean Bouchard Bloom | Developer | |
| Sean Brown | Developer | |
| Sean Conran | Developer | |
| Sean Ellis | Developer | |
| Sean Finch | Developer | |
| Sean Garland | Developer | |
| Sean Heron | Developer | |
| Sean McColgan | Developer | |
| Sean Noonan | Developer | |
| Sean Pearce | Developer | |
| Sean Puckett | Developer | |
| Sean Scapelhorn | Developer | |
| Sean173 | Developer | |
| SeanMacLean | Developer | |
| SeanSS | Developer | |
| SeanYoSG | Developer | |
| Seaniemaurice | Developer | |
| SeansHome | Developer | |
| SeanyCornman | Developer | |
| SearchForSignsCo | Developer | |
| Seashell Studio | DeveloperPublisher | |
| SeasonQuest | Developer | |
| Seast | Developer | |
| SeastarSwe | Developer | |
| Seatongrove Ltd. | Publisher | |
| SeattleTroy | Developer | |
| Seaven Studio | DeveloperPublisher | |
| Seb Woodland | Developer | |
| SebP | Developer | |
| Seba Games Dev | Developer | |
| Seba Labo | Developer | |
| SebaGamesDev | Developer | |
| Sebadst | Developer | |
| Sebagamedev | Developer | |
| Sebagamesdev | Developer | |
| Sebajuste | Developer | |
| SebasDev | Developer | |
| SebasRez | Developer | |
| Sebastian | Developer | |
| Sebastian Biala-Learmonth | Developer | |
| Sebastian Caron | Developer | |
| Sebastian Lague | Developer | |
| Sebastian Martinez | Developer | |
| Sebastian Scaini | Developer | |
| Sebastien Vermeulen | Developer | |
| Second Dimension Games | Developer | |
| Second Dimension R&T, LLC | Developer | |
| Second Garage | Developer | |
| Second Maze | Developer | |
| Second Order | DeveloperPublisher | |
| Second Shrine | Developer | |
| Second Step Studios | Developer | |
| Secret Base | Developer | |
| Secret Exit | DeveloperPublisher | |
| Secret Foxfire | Developer | |
| Secret Level | Developer | |
| Secret Stash Games | Publisher | |
| Secret Tunnel | Developer | |
| Secret Tunnel Entertainment | DeveloperPublisher | |
| SecretBasment | Developer | |
| SecretJuice1 | Developer | |
| SecretPocketCat | Developer | |
| Section 3 | Developer | |
| SectorCodec | Developer | |
| Sectordub | Developer | |
| Sedge | Developer | |
| Sedgwick2K | Developer | |
| Seed Interactive | Developer | |
| Seed Studios | Developer | |
| Seed by Seed | DeveloperPublisher | |
| Seed9 Entertainment | DeveloperPublisher | |
| SeedBolt Studios | Developer | |
| SeedOflemon | Developer | |
| SeedStudios | Developer | |
| Seeds of Love | Developer | |
| Seemingly Pointless | Developer | |
| Seere | Developer | |