| Shotgun Mango Ltd | Developer | |
| Shotgun With Glitters | Developer | |
| Shotgun with Glitters | Developer | |
| Shots on Sunday | Developer | |
| Shou | Developer | |
| Shouei | DeveloperPublisher | |
| Shouei System | DeveloperPublisher | |
| ShoueiJP | Publisher | |
| Shout! Designworks | Developer | |
| Show Show Labs | Developer | |
| Showerthoughts Studios | Developer | |
| ShoyuTotte | Developer | |
| Shrapnel Games | Publisher | |
| Shreesh_Fuup | Developer | |
| Shregolag | Developer | |
| Shreveport Arcade | Developer | |
| ShrimpPlugGames | Developer | |
| ShrimpTraveller | Developer | |
| Shroomius | Developer | |
| Shubh0809 | Developer | |
| Shubham Vine | Developer | |
| Shubshub | Developer | |
| ShuddaHaddaLottaFun | Developer | |
| Shuddahaddalottafun | DeveloperPublisher | |
| Shueisha | Developer | |
| Shugor | Developer | |
| Shuhei Miyazawa | Developer | |
| Shukimo Studio | Developer | |
| Shunsu | Developer | |
| Shunyanha | Developer | |
| Shurooq Juma | Developer | |
| Shuu_37 | Developer | |
| Shuwa System | DeveloperPublisher | |
| Shuwa System Trading Co. | Publisher | |
| Shuyi Chang | Developer | |
| Shuzzy | Developer | |
| Shweep | Developer | |
| Shxynez | Developer | |
| Shy Egg | DeveloperPublisher | |
| Shy Tea Games | Developer | |
| ShyGuyFreak | Developer | |
| Shynif | Developer | |
| Si-Lab | Developer | |
| SiChris Productions | Developer | |
| SiJOGA | Developer | |
| SiMouth | Developer | |
| SiN Studios | Developer | |
| SiTheHandsomeGuy | Developer | |
| Siactro | Developer | |
| Siamés Studio | Developer | |
| Siberian Entertainment | Developer | |
| SiberianGriever | Developer | |
| Sibling Rivalry Games | Developer | |
| Sicerat | Developer | |
| Sick Chicken Studios | Developer | |
| Sick Puppies | Developer | |
| SickLion | Developer | |
| SicklyGeek | Developer | |
| Sid | Developer | |
| Sid Bostwick | Developer | |
| Sid Fish Games | Developer | |
| Sid Meier | Developer | |
| Sidaal | Developer | |
| SiddSaxena | Developer | |
| Siddarth R Govindan | Developer | |
| Side Group | Developer | |
| Side Hit Studios | DeveloperPublisher | |
| Side Kick LTD | Developer | |
| SideCo | Developer | |
| SideQuest | Developer | |
| SideQuest Studios | Developer | |
| SideUpDown | Developer | |
| Sidebar Games | DeveloperPublisher | |
| Sidhe | DeveloperPublisher | |
| Sidhe Interactive | Developer | |
| Siduron | Developer | |
| Sieber2210 | Developer | |
| Sieg | DeveloperPublisher | |
| Siegfried Croes | Developer | |
| Siegfried Kurtz | Developer | |
| Sienna Blossom | Developer | |
| Sierra | DeveloperPublisher | |
| Sierra Attractions | Publisher | |
| Sierra Entertainment | DeveloperPublisher | |
| Sierra EntertainmentEU | Publisher | |
| Sierra EntertainmentEU,NA | Publisher | |
| Sierra EntertainmentPAL | Publisher | |
| Sierra Entertainment|Universal Interactive | Publisher | |
| Sierra Northwest | Developer | |
| Sierra On-Line | DeveloperPublisher | |
| Sierra On-line | DeveloperPublisher | |
| Sierra Online | DeveloperPublisher | |
| Sierra Sports | Publisher | |
| Sierra Studios | DeveloperPublisher | |
| SierraLee | Developer | |
| SierraVenture | Publisher | |
| Siesta | Developer | |
| Siff | Developer | |
| Sigeria | Developer | |
| SigilCipher | Developer | |
| Sigma | Publisher | |
| Sigma Enterprises | DeveloperPublisher | |
| Sigma Enterprises Inc. | Publisher | |
| Sigma Enterprises JP | Publisher | |
| Sigma EnterprisesJP | Publisher | |
| Sigma Pro-Tech | Developer | |
| Sigma Team | DeveloperPublisher | |
| SigmaSuccour | Developer | |
| Sign hunter | Developer | |
| Signa Works | Developer | |
| Signal Studios | Developer | |
| Signalised | Developer | |
| Signed and Sealed With a Kiss | Developer | |
| Significant Games | Developer | |
| Significant Gravitas | Developer | |
| Signol_Games | Developer | |
| Sigono | Developer | |
| Sigrids Änglar | Developer | |
| Sigrún Tinna Gissurardóttir | Developer | |
| Sigtrap Games | Developer | |
| Sigur Studio | Developer | |
| Siieg | Developer | |
| Siile | Developer | |
| Siisi4 | Developer | |
| Sijawa Production | Developer | |
| Sik | Developer | |
| Sikeology | Developer | |
| Silas Grarup | Developer | |
| Silas Warner | Developer | |
| Silasmakegame | Developer | |
| Silasman | Developer | |
| Silberspiele | Developer | |
| SilbinaryWolf | Developer | |
| Silence | Developer | |
| SilenceArts | Developer | |
| Sileni Studios | Developer | |
| Silent Dreams | Developer | |
| Silent Future | Developer | |
| Silent Interactive | Developer | |
| Silent Knight Games | Developer | |
| Silent Lizard | Developer | |
| Silent Minstrel | Developer | |
| Silent Software | Developer | |
| Silent Software Inc | Developer | |
| Silent Software, Inc. | Developer | |
| Silent Tower Games | Developer | |
| SilentYetJudgy | Developer | |
| Silentman | Developer | |
| Silesia Games | DeveloperPublisher | |
| Silhouette Software (John F Cain, Simon Price) | Developer | |