| Special FX Software (James Bagley, Colin Rushby, Keith Tinman) | Developer | |
| Special FX Software (Jim Bagley, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Charles Davies, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Karen Davies, Keith Tinman) | Developer | |
| Special FX Software (Jonathan Smith, Karen Davies, Tony Pomfret, Stephen Wahid) | Developer | |
| Special Projects | Developer | |
| Specialbit | Developer | |
| Specor Technology | Developer | |
| Spectacular Games | Developer | |
| Spectral Bunny Studios | Developer | |
| Spectral Dimensions | Developer | |
| Spectral Studio | Developer | |
| SpectralVisage | Developer | |
| Spectravideo | DeveloperPublisher | |
| SpectreVision | Developer | |
| Spectrem | Developer | |
| Spectris Games | Developer | |
| Spectrum Games | Publisher | |
| Spectrum Games Ltd | Publisher | |
| Spectrum HoloByte | DeveloperPublisher | |
| Spectrum HoloByte NA | Publisher | |
| Spectrum HoloByteNA | Publisher | |
| Spectrum Holobyte | DeveloperPublisher | |
| Spectrum Holobyte, Inc. | Publisher | |
| Spectrum Pacific Publishing | Publisher | |
| Speculative Simulations Ltd | Developer | |
| Speed | Developer | |
| SpeedStrip Interactive | DeveloperPublisher | |
| Speedev | Developer | |
| Speedwagon Foundation | Developer | |
| Speedy Raptors Collective | Developer | |
| SpeedyBrain | Developer | |
| Speelbaars | Developer | |
| SpektacularGames | Developer | |
| Spektor | Developer | |
| Spelkonditoriet | Developer | |
| Spelkraft | Developer | |
| Spellborn International | Developer | |
| Spellbound | Developer | |
| Spellbound Entertainment | Developer | |
| Spellbound Entertainment AG | Developer | |
| Spellbound Interactive | Developer | |
| Spellsoft | Developer | |
| Spence | Developer | |
| Spencer Alves | Developer | |
| Spencer Winson | Developer | |
| SpencerG4N | Developer | |
| Spenn | Developer | |
| Spennerino | Developer | |
| Spera_blues | Developer | |
| Sphere | Developer | |
| Sphere Inc. | Developer | |
| Sphere, Inc. | Developer | |
| Spheresoft | Developer | |
| SpherianGames | Developer | |
| Sphysics | Developer | |
| SpiRiTs | Developer | |
| Spica Studios | Developer | |
| Spice Games | Developer | |
| Spicy Ferret | Developer | |
| Spicy Gyro Games | Developer | |
| Spicy Horse | Developer | |
| Spicy Lemon | Developer | |
| Spicy Overlord | Developer | |
| Spicy Roll | Developer | |
| Spicy Tails | Developer | |
| SpicyCatGames | Developer | |
| SpicyCatStudios | Developer | |
| SpicyFrog | Developer | |
| SpicyOnTheRicey | Developer | |
| Spicyfuse | Developer | |
| Spicysoft | DeveloperPublisher | |
| Spider Lily Studios | Developer | |
| SpiderFlorist | Developer | |
| SpiderMonk Entertainment | Developer | |
| Spiderlili | Developer | |
| Spidermonk Entertainment | Developer | |
| Spiders | Developer | |
| Spidersoft | Developer | |
| Spidersoft (Gavin Wade, Chris Edwards) | Developer | |
| Spidersoft (Jonathan Court, Nick Cooke, Martin Walker, Jonathan P. Dean, C. Gibbs, R. Gill, Greame Ashton) | Developer | |
| Spiderweb Software | DeveloperPublisher | |
| Spidi | Developer | |
| Spiel | Developer | |
| Spielkind | Developer | |
| Spierek | Developer | |
| Spiffcode | Developer | |
| Spike | DeveloperPublisher | |
| Spike Chunsoft | DeveloperPublisher | |
| Spike Games | Publisher | |
| Spike JP | Publisher | |
| Spike Studio | Developer | |
| SpikeJP | Publisher | |
| SpikeJP,KO | Publisher | |
| Spikewave Games | DeveloperPublisher | |
| Spiky Games | Developer | |
| SpikySnail Games | Developer | |
| Spilim | Developer | |
| Spilt Milk Studios | Developer | |
| SpinTop Games | Developer | |
| SpinVector | Developer | |
| Spina | Developer | |
| SpindleyQ | Developer | |
| Spinfoam Games | Developer | |
| Spinnaker | Developer | |
| Spinnaker Software | DeveloperPublisher | |
| Spinnaker Software Corporation | DeveloperPublisher | |
| Spinning Coin | Developer | |
| Spinning Punch Studios | Developer | |
| Spiral (Jose Antonio Acedo) | Developer | |
| Spiral Atlas | Developer | |
| Spiral House | Developer | |
| Spiral Summit Games | Developer | |
| SpiralPuzzle | Developer | |
| Spire Interactive | Developer | |
| Spirit Stone Studio | Developer | |
| Spirit of Discovery | Publisher | |
| Spirit of Discovery (Game developers) | Developer | |
| Spirit.creations | Developer | |
| SpitBlaze | Developer | |
| SpitefulFox | Developer | |
| Spitko | Developer | |
| Spius | Developer | |
| Spiyon465 | Developer | |
| Splash (video game company) | Publisher | |
| Splash Damage | Developer | |
| SplashTeam | Developer | |
| Splashcats | Developer | |
| Splashteam | Developer | |
| Spleeen | Developer | |
| Spleen Machine | Developer | |
| SplendidAutomaton | Developer | |
| SplendidDog | Developer | |
| Splendy Games | Developer | |
| Splerp | Developer | |
| Splickety | Developer | |
| Splinter Vision | Developer | |
| Split | Developer | |
| Split82 | Developer | |
| SplitHare | Developer | |
| Splixun | Developer | |
| Splodey | Developer | |
| Splumsy | Developer | |
| Spoland | Developer | |
| Spolity Default | Developer | |
| Spongey Kitty | Developer | |
| Sponny Bard Productions | Developer | |
| SpoocleMacBoogle | Developer | |
| SpookifyDev | Developer | |
| Spooklight Games | Developer | |
| Spookto | Developer | |
| Spooky Cat | Developer | |
| Spooky Cookie Games | Developer | |
| Spooky Doorway | DeveloperPublisher | |
| Spooky Games | Developer | |
| Spooky Squid Games Inc. | Developer | |
| SpookyAl | Developer | |
| SpookyBee | Developer | |
| SpookyBunsGames | Developer | |
| SpookySlaughtumn | Developer | |
| SpookyTanookie | Developer | |
| Spookybot | Developer | |
| SpoonProduction36 | Developer | |
| Spoonbox Studio | Developer | |
| Spoonman Games | Developer | |
| Spoony Bard Productions | Developer | |
| SportTime | DeveloperPublisher | |
| Sports Director Limited | Developer | |
| Sports Interactive | Developer | |
| Sportshorts | Developer | |
| Sportsmaster | Publisher | |
| Spotlight Software | Publisher | |
| Spotlightor Interactive | Developer | |
| Spotted Shark Studios | DeveloperPublisher | |
| Spotted Zebra | Developer | |
| Spottedphyre | Developer | |
| Spotty Doggy and Witty Doggy | Developer | |
| Sprakelsoft | DeveloperPublisher | |
| Spram | Developer | |
| Spratley | Developer | |
| Sprawl | Developer | |
| Spray | Developer | |
| Sprazzal | Developer | |
| SpreadShot | Developer | |
| Spreadable Fruit | Developer | |
| Spreadcamp | Developer | |
| Spring | Developer | |
| SpringHeeled | Developer | |
| Springarm | Developer | |
| Springboard Software | Publisher | |
| Springloaded | DeveloperPublisher | |
| Springtail | Developer | |
| SprintToTheTop | Developer | |
| Sprite | Developer | |
| SpriteQ | Developer | |
| Sprited | Developer | |
| SpritersBlock | Developer | |
| Sproing | Developer | |
| Sproing Interactive | Developer | |
| Sproing Interactive Media | Developer | |