| Siberian Entertainment | Developer | |
| SiberianGriever | Developer | |
| Sibling Rivalry Games | Developer | |
| Sicerat | Developer | |
| Sick Chicken Studios | Developer | |
| Sick Puppies | Developer | |
| SickLion | Developer | |
| SicklyGeek | Developer | |
| Sid | Developer | |
| Sid Bostwick | Developer | |
| Sid Fish Games | Developer | |
| Sid Meier | Developer | |
| Sidaal | Developer | |
| SiddSaxena | Developer | |
| Siddarth R Govindan | Developer | |
| Side Group | Developer | |
| Side Hit Studios | DeveloperPublisher | |
| Side Kick LTD | Developer | |
| SideCo | Developer | |
| SideQuest | Developer | |
| SideQuest Studios | Developer | |
| SideUpDown | Developer | |
| Sidebar Games | DeveloperPublisher | |
| Sidhe | DeveloperPublisher | |
| Sidhe Interactive | Developer | |
| Siduron | Developer | |
| Sieber2210 | Developer | |
| Sieg | DeveloperPublisher | |
| Siegfried Croes | Developer | |
| Siegfried Kurtz | Developer | |
| Sienna Blossom | Developer | |
| Sierra | DeveloperPublisher | |
| Sierra Attractions | Publisher | |
| Sierra Entertainment | DeveloperPublisher | |
| Sierra EntertainmentEU | Publisher | |
| Sierra EntertainmentEU,NA | Publisher | |
| Sierra EntertainmentPAL | Publisher | |
| Sierra Entertainment|Universal Interactive | Publisher | |
| Sierra Northwest | Developer | |
| Sierra On-Line | DeveloperPublisher | |
| Sierra On-line | DeveloperPublisher | |
| Sierra Online | DeveloperPublisher | |
| Sierra Sports | Publisher | |
| Sierra Studios | DeveloperPublisher | |
| SierraLee | Developer | |
| SierraVenture | Publisher | |
| Siesta | Developer | |
| Siff | Developer | |
| Sigeria | Developer | |
| SigilCipher | Developer | |
| Sigma | Publisher | |
| Sigma Enterprises | DeveloperPublisher | |
| Sigma Enterprises Inc. | Publisher | |
| Sigma Enterprises JP | Publisher | |
| Sigma EnterprisesJP | Publisher | |
| Sigma Pro-Tech | Developer | |
| Sigma Team | DeveloperPublisher | |
| SigmaSuccour | Developer | |
| Sign hunter | Developer | |
| Signa Works | Developer | |
| Signal Studios | Developer | |
| Signalised | Developer | |
| Signed and Sealed With a Kiss | Developer | |
| Significant Games | Developer | |
| Significant Gravitas | Developer | |
| Signol_Games | Developer | |
| Sigono | Developer | |
| Sigrids Änglar | Developer | |
| Sigrún Tinna Gissurardóttir | Developer | |
| Sigtrap Games | Developer | |
| Sigur Studio | Developer | |
| Siieg | Developer | |
| Siile | Developer | |
| Siisi4 | Developer | |
| Sijawa Production | Developer | |
| Sik | Developer | |
| Sikeology | Developer | |
| Silas Grarup | Developer | |
| Silas Warner | Developer | |
| Silasmakegame | Developer | |
| Silasman | Developer | |
| Silberspiele | Developer | |
| SilbinaryWolf | Developer | |
| Silence | Developer | |
| SilenceArts | Developer | |
| Sileni Studios | Developer | |
| Silent Dreams | Developer | |
| Silent Future | Developer | |
| Silent Interactive | Developer | |
| Silent Knight Games | Developer | |
| Silent Lizard | Developer | |
| Silent Minstrel | Developer | |
| Silent Software | Developer | |
| Silent Software Inc | Developer | |
| Silent Software, Inc. | Developer | |
| Silent Tower Games | Developer | |
| SilentYetJudgy | Developer | |
| Silentman | Developer | |
| Silesia Games | DeveloperPublisher | |
| Silhouette Software (John F Cain, Simon Price) | Developer | |
| Silicon & Synapse | Developer | |
| Silicon Beach Software | Developer | |
| Silicon Dreams | Developer | |
| Silicon Dreams Studio | Developer | |
| Silicon Galaxy | Developer | |
| Silicon Ice Development | Developer | |
| Silicon Joy | Publisher | |
| Silicon Knights | DeveloperPublisher | |
| Silicon Software | Developer | |
| Silicon Sorcery | Developer | |
| Silicon Studio | Developer | |
| SiliconWorx | Developer | |
| Silivar | Developer | |
| Silk | Developer | |
| Silken Sail Entertainment | Developer | |
| SilkevdSmissen | Developer | |
| Silkworm Sweatshop | Developer | |
| Silky Smooth Studio | Developer | |
| Silky's | DeveloperPublisher | |
| SillikOne | Developer | |
| SillyGame | Developer | |
| SillyGlassBoy | Developer | |
| Sillysoft Games | DeveloperPublisher | |
| Silmarils | DeveloperPublisher | |
| Silmarils Software | Publisher | |
| Siltocyn | Developer | |
| Silvarc | Developer | |
| Silver Cow Studio | DeveloperPublisher | |
| Silver Creek Entertainment | Developer | |
| Silver Dollar Games | DeveloperPublisher | |
| Silver Gear Interactive | Developer | |
| Silver Lemur Games | Developer | |
| Silver Lightning Software | DeveloperPublisher | |
| Silver Sphere Studios | DeveloperPublisher | |
| Silver Star | DeveloperPublisher | |
| Silver Star Japan | DeveloperPublisher | |
| Silver Style Entertainment | Developer | |
| Silver Wish Games | Developer | |
| Silver-Streak | Developer | |
| SilverBack Studios | Developer | |
| SilverBirch Studios | Developer | |
| SilverBrocks | Developer | |
| SilverBullet | Developer | |
| SilverHyena | Developer | |
| SilverLine Software | Publisher | |
| SilverLining | Developer | |
| SilverSnakeGameS | Developer | |
| SilverStar | DeveloperPublisher | |
| SilverStarJapan | Developer | |
| SilverTabbyCat ~ Visual Novel Games | Developer | |
| Silverball Studios | Developer | |
| Silverbirch Studios | Developer | |
| Silverbird | Publisher | |
| Silverbird Software | Publisher | |
| Silverm | Developer | |
| Silversober | Developer | |
| Silversoft | Publisher | |
| Silversoft Ltd | Publisher | |
| Silverstring Media | Developer | |
| Silverware Games | Developer | |
| Silvijn | Developer | |
| Silvio257 | Developer | |
| SilviuZLD | Developer | |
| Sim0wn3d | Developer | |
| SimBin | Developer | |
| SimBin Studios | DeveloperPublisher | |
| SimDevs | DeveloperPublisher | |
| SimFabric | DeveloperPublisher | |
| SimGraph | Developer | |
| SimLab Games | Developer | |
| SimSoftGames | Developer | |
| SimTex | Developer | |
| Sima | Developer | |
| Sima Games | Developer | |
| Simbi | Developer | |
| Simbin | Developer | |
| Simbiosis Interactive | Developer | |
| SimeStudios | Developer | |
| Simex | Developer | |
| Similia | Developer | |
| Similis | Developer | |
| Siminu | Developer | |
| Simis | Developer | |
| Simmer Software (Jeff Calder, George Calvert, Andy Wynd) | Developer | |
| Simo K. Tuima | Developer | |
| Simogo | DeveloperPublisher | |
| Simon & Schuster | DeveloperPublisher | |
| Simon & Schuster Interactive | DeveloperPublisher | |
| Simon 'GoZz' Mielcarek | Developer | |
| Simon Brattel | Developer | |
| Simon Butler | Developer | |
| Simon Chauvin | Developer | |
| Simon Chen | Developer | |
| Simon Cobb | Developer | |
| Simon Conway | Developer | |
| Simon Creative | Developer | |
| Simon Daniels | Developer | |
| Simon Dunstan | Developer | |
| Simon Ernst | Developer | |
| Simon Freeman | Developer | |