| EntenNugget | Developer | |
| Enter CTRL | Developer | |
| Enter Main Loop | Developer | |
| EnterTheVoid-x86 | Developer | |
| Enterbrain | DeveloperPublisher | |
| EnterbrainJP | Publisher | |
| Entergram | DeveloperPublisher | |
| Enterim | Developer | |
| Entertainment Enterprises, Ltd. | Publisher | |
| Entertainment Forge | Developer | |
| Entertainment Int | Developer | |
| Entertainment International | Developer | |
| Entertainment International UK | Publisher | |
| Entertainment Software Publishing | DeveloperPublisher | |
| Entertainment USA | Publisher | |
| Enthe | Developer | |
| Entity | Developer | |
| EntranceJew | Developer | |
| Entropic Arts | Developer | |
| Entropy Phi | Developer | |
| EntwicklerX | DeveloperPublisher | |
| Enya Games | Developer | |
| Enypsox | DeveloperPublisher | |
| Enzitoc | Developer | |
| EnzoUP | Developer | |
| Eokinyi35 | Developer | |
| Eolith | DeveloperPublisher | |
| Eon | Developer | |
| Eon Digital Entertainment | Publisher | |
| Eon Digital EntertainmentEU | Publisher | |
| Eon Software | Developer | |
| EonPAL | Publisher | |
| Ephoria Games | Developer | |
| EpiXR | Publisher | |
| EpiXR Games | DeveloperPublisher | |
| Epic | DeveloperPublisher | |
| Epic Blank Crew | Developer | |
| Epic Games | DeveloperPublisher | |
| Epic Interactive Strategy | DeveloperPublisher | |
| Epic LLama | Developer | |
| Epic Llama | Developer | |
| Epic MegaGames | DeveloperPublisher | |
| Epic Multimedia Group | Developer | |
| Epic Wolf Studio | Developer | |
| Epic/Sony Records JP | Publisher | |
| EpicBryan88 | Developer | |
| EpicCrownKing | Developer | |
| EpicLords Studios | Developer | |
| EpicRaisin | Developer | |
| EpicStudios | Developer | |
| EpicTastyPapple | Developer | |
| Epic_Gamer101 | Developer | |
| Epicenter Interactive | Developer | |
| Epicenter Studios | Developer | |
| Epicoro | Developer | |
| Epics | Developer | |
| Epiczsmo | Developer | |
| Epiin | Developer | |
| EpilogueSoft | Developer | |
| Epiphany Games | DeveloperPublisher | |
| EpiphanyG | Developer | |
| Epitasis Games | Developer | |
| Epixr | DeveloperPublisher | |
| Epixr Games | Publisher | |
| Epoch | DeveloperPublisher | |
| Epoch & SAS Sakata | Developer | |
| Epoch Co. | DeveloperPublisher | |
| Epoch Co. (JP) | Publisher | |
| Epoch Co., Ltd. | Publisher | |
| Epoch Co.JP | Publisher | |
| Epoch JP | Publisher | |
| Eponick's Lab | Developer | |
| Epos | Publisher | |
| Epos Corporation | Publisher | |
| Eppu Peltonen | Developer | |
| Epyx | DeveloperPublisher | |
| Equii | Developer | |
| Equilaterus Game Studios | Developer | |
| Equilibrium | Developer | |
| Equinox Digital Entertainment | Developer | |
| EquipoPsyche | Developer | |
| Equity | Publisher | |
| Equity Games | Publisher | |
| ErPabuls | Developer | |
| ErThu | Developer | |
| Erasmo Bellumat | Developer | |
| ErasmusCrowley | Developer | |
| Erathor_Noname | Developer | |
| Erbe Software | Publisher | |
| ErdemKaya | Developer | |
| Erdnusshonig | Developer | |
| EreMix | Developer | |
| Erendelous | Developer | |
| Erenor Games | Developer | |
| Erenso | Developer | |
| Erethan | Developer | |
| Ergo | Developer | |
| Ergurcay | Developer | |
| Eric | Developer | |
| Eric "Badspot" Hartman | Developer | |