| Selavi Games | Developer | |
| Seldon | Developer | |
| Selectricity Productions | Developer | |
| Selectsoft | Publisher | |
| Selectsoft Publishing | Publisher | |
| Selen | DeveloperPublisher | |
| SelenJP | DeveloperPublisher | |
| SeleneVirus | Developer | |
| Selenity | Developer | |
| Selexy | Developer | |
| Self | Publisher | |
| Self Made Miracle | Developer | |
| Self-published | Publisher | |
| SelfPC | Developer | |
| Selfish Dream | Developer | |
| Selina | Developer | |
| Selkcip | Developer | |
| Seltzy | Developer | |
| Selvysus | Developer | |
| Selwes | Developer | |
| SemLaan | Developer | |
| Semaeopus | Developer | |
| Semag Games | Developer | |
| Semaphore | Developer | |
| Semenar | Developer | |
| SemiCom | Publisher | |
| SemiSinful | Developer | |
| Semicolon42 | Developer | |
| Semicom | Publisher | |
| Semisoft | Developer | |
| SemiteCoding | Developer | |
| Semmelknoedelstampfer | Developer | |
| SempiternityGMS | Developer | |
| Sen | Developer | |
| SenadMMG | Developer | |
| Senekagames | Developer | |
| Sengaya Games | Developer | |
| Senior Salvador | Developer | |
| Senior-X | Developer | |
| Sennari Interactive | Developer | |
| Sennin | Developer | |
| Sense Games | Developer | |
| Sense_101 | Developer | |
| SenseiSquishy | Developer | |
| Sensen Games | Developer | |
| Sensible Software | DeveloperPublisher | |
| Sensible Software (Richard Joseph) | Developer | |
| Sensory Sweep | Developer | |
| Sensory Sweep Studios | Developer | |
| Sensui Software | Developer | |
| Sente Systems | Publisher | |
| Sentient Software | Developer | |
| Sentient Software (Andrew Postlewhite, Clive Paul, Jonathan Dunn) | Developer | |
| Sentient Software (Andrew Postlewhite, Robert Moneagle, Ben Daglish) | Developer | |
| Sentient Software (Elliot Gay, Allistair Watt) | Developer | |
| Sentient Software (John Mullins, Clive Paul, Mark R. Jones, Peter Clarke) | Developer | |
| Sentient Software (John Mullins, Clive Paul, T Fagelman) | Developer | |
| Sentient Software (John Mullins, Robert Moneagle, Flora Stoneman, Clive Paul, Alick Morrall) | Developer | |
| Sentient Software (Mark Kirkby, Robert Moneagle, Flora Stoneman, Clive Paul, Alick Morrall, Dawn Drake) | Developer | |
| Sentient Software (Michael Berlyn & Harry Walker) | Developer | |
| Sentient Software (Mike Lamb, Jonathan Dunn, Bill Harbison, John Mullins, Alick Morrall) | Developer | |
| Sentient Software Ltd. | Publisher | |
| Sentrigan | Developer | |
| SentryTurbo | Developer | |
| Senydesu | Developer | |
| Senzouz | Developer | |
| Seongwoon | Developer | |
| Seph Boss | Developer | |
| Sephta | Developer | |
| Sepi | Developer | |
| Sepia Mage | Developer | |
| SepiaGames | Developer | |
| Seppi-gamestudios | Developer | |
| SeprAY | Developer | |
| SepulvedaJoshua | Developer | |
| SeracStudio | Developer | |
| Serafín Álvarez | Developer | |
| Seraph Team | Developer | |
| SeraphCircle | Developer | |
| SeraphInSolace | Developer | |
| SeraphinaKitten | Developer | |
| Seraphinite | Developer | |
| Serdetay | Developer | |
| Serellan | Developer | |
| Serena Samborski | Developer | |
| Serenaagh | Developer | |
| Serenadev | Developer | |
| Serendevity | Developer | |
| Serendipity Software | DeveloperPublisher | |
| Serendipy Studios | Developer | |
| Serene | DeveloperPublisher | |
| Serenity Forge | DeveloperPublisher | |
| SergFras | Developer | |
| Serge Dosang | Developer | |
| Sergei Ryzhkov | Developer | |
| Sergent Cule | Developer | |
| Sergenti | Developer | |
| Sergey | Developer | |
| Sergey Lerg | Developer | |
| Sergey Noskov | Developer | |